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Academic Article Importance of glutathione and associated enzymes in drug response.
Academic Article Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression.
Academic Article Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues.
Academic Article Estramustine resistance correlates with tau over-expression in human prostatic carcinoma cells.
Academic Article The antioxidant effects of Crassostrea gigas extract (JCOE) in human volunteers.
Academic Article Cellular response to a glutathione S-transferase P1-1 activated prodrug.
Academic Article Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.
Academic Article Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus.
Academic Article Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2).
Academic Article Evidence for a glycoconjugate form of glutathione S-transferase pI.
Academic Article Estrogens and environmental estrogens.
Academic Article Protein interaction-targeted drug discovery: evaluating critical issues.
Academic Article Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to chromatin and nucleosomal fractions of HeLa cells.
Academic Article Regulation of JNK signaling by GSTp.
Academic Article Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.
Academic Article Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein.
Academic Article The antioxidant role of selenium and seleno-compounds.
Academic Article Molecular modes of action of artesunate in tumor cell lines.
Academic Article Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus.
Academic Article Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.
Academic Article Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.
Academic Article Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress.
Academic Article The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance.
Academic Article Evaluation of lipophilins as determinants of tumor cell response to estramustine.
Academic Article Interaction of forskolin with the P-glycoprotein multidrug transporter.
Academic Article Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response.
Academic Article Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Academic Article Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase.
Academic Article Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level.
Academic Article Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Academic Article Cytotoxicity and DNA damaging effects of a new nitrosourea, fotemustine, diethyl- 1-(3-(2-chloroethyl)-3-nitrosoureido) ethylphosphonate-S10036.
Academic Article Glutathione-s-transferases as determinants of cell survival and death.
Academic Article Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.
Academic Article Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.
Academic Article Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards.
Academic Article Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.
Academic Article Integration of amplified differential gene expression (ADGE) and DNA microarray.
Academic Article The importance of glutathione in human disease.
Academic Article Causes and consequences of cysteine S-glutathionylation.
Academic Article A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas.
Academic Article Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line.
Academic Article Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Academic Article Immunofluorescent studies of the anti-microtubule effects of the anti-cancer drug estramustine.
Academic Article Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.
Academic Article Biochemical and cytotoxic properties of the isomeric forms of N,N'-bis[N-2-chloroethyl)-N-nitrosocarbamoyl] cystamine.
Academic Article Phytosterols in the prevention of human pathologies.
Academic Article Enhancement of nitrosourea cytotoxicity in vitro using hydrocortisone.
Academic Article Correlation of nitrosourea murine bone marrow toxicity with deoxyribonucleic acid alkylation and chromatin binding sites.
Academic Article Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.
Academic Article Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs.
Academic Article cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
Academic Article Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
Academic Article Analysis of glyoxalase-I from normal and tumor tissue from human colon.
Academic Article Glutathione and related enzymes in multidrug resistance.
Academic Article Increased glutathione expression in cells induced by Crassostera gigas extract (JCOE).
Academic Article Interaction of estramustine with tubulin isotypes.
Academic Article Trace elements in human physiology and pathology. Copper.
Academic Article Trace elements in human physiology and pathology: zinc and metallothioneins.
Academic Article Association of ABCA2 expression with determinants of Alzheimer's disease.
Academic Article Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).
Academic Article Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
Academic Article Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Academic Article Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.
Academic Article Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine.
Academic Article Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
Academic Article Redox metabolism and malignancy.
Academic Article ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration.
Academic Article The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.
Academic Article Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity.
Academic Article Intracellular effects of estramustine (Estracyt/Emcyt).
Academic Article Estramustine--a nitrogen mustard/steroid with antimicrotubule activity.
Academic Article Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.
Academic Article Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells.
Academic Article Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.
Academic Article Purification of glutathione S-transferases from rat liver and Walker 256 mammary carcinoma cells by high-performance liquid chromatography and a glutathione affinity column.
Academic Article Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine.
Academic Article Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity.
Academic Article Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine.
Academic Article Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets.
Academic Article Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas.
Academic Article Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.
Academic Article Antimicrotubule effects of estramustine, an antiprostatic tumor drug.
Academic Article Alkylating agent interactions with the nuclear matrix.
Academic Article Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Academic Article Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets.
Academic Article Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.
Academic Article Influence of hydrocortisone on the binding of nitrosoureas to nuclear chromatin subfractions.
Academic Article Preclinical and clinical perspectives on the use of estramustine as an antimitotic drug.
Academic Article Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines.
Academic Article Cellular and in vitro transport of glutathione conjugates by MRP.
Academic Article ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.
Academic Article Promoter analysis of a human dihydrodiol dehydrogenase.
Concept Antineoplastic Combined Chemotherapy Protocols
Concept Gene Expression Profiling
Concept Journal Impact Factor
Concept Cytokines
Concept Piperazines
Concept Glutamine
Concept Blotting, Southern
Concept Financing, Government
Concept Methylnitronitrosoguanidine
Concept Enzyme-Linked Immunosorbent Assay
Concept Age Factors
Concept Karyotyping
Concept Disease Models, Animal
Concept Intestinal Mucosa
Concept Fibroblasts
Concept Dexamethasone
Concept I-kappa B Kinase
Concept Drug Administration Schedule
Concept Temperature
Concept Sequence Analysis, DNA
Concept Protein Phosphatase 1
Concept Protein S
Concept Databases, Factual
Concept Methionine
Concept Amyloid beta-Protein Precursor
Concept Microscopy, Electron
Concept Benzene Derivatives
Concept Gene Amplification
Concept Methionine Sulfoximine
Concept Lung Neoplasms
Concept Filipin
Concept Cyclin-Dependent Kinase 6
Concept Estrogens, Non-Steroidal
Concept Protein Processing, Post-Translational
Concept Cell Lineage
Concept Pulmonary Fibrosis
Concept Ultraviolet Rays
Concept Restriction Mapping
Concept Alkylating Agents
Concept Flow Cytometry
Concept Unfolded Protein Response
Concept Pulmonary Disease, Chronic Obstructive
Concept Phosphoprotein Phosphatases
Concept Introns
Concept Glutamic Acid
Concept Mitogen-Activated Protein Kinases
Concept Isoflavones
Concept Oncogenes
Concept Drugs, Investigational
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Rats, Inbred Strains
Concept Taurine
Concept Cell Division
Concept p38 Mitogen-Activated Protein Kinases
Concept Magnetic Resonance Imaging
Concept Cross-Over Studies
Concept Drosophila melanogaster
Concept Drug Therapy, Combination
Concept Orosomucoid
Concept Metabolic Clearance Rate
Concept DNA Helicases
Concept Nitric Oxide
Concept Epoprostenol
Concept RNA Interference
Concept Mice, Inbred BALB C
Concept Polymorphism, Single Nucleotide
Concept Pyrazoles
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Penis
Concept Kidney Diseases
Concept Sensitivity and Specificity
Concept Lignans
Concept alpha 1-Antichymotrypsin
Concept Cell Survival
Concept Antineoplastic Agents, Alkylating
Concept Clinical Trials, Phase I as Topic
Concept Treatment Outcome
Concept Mitogen-Activated Protein Kinase Kinases
Concept Macrophages
Concept Leukotriene C4
Concept National Institutes of Health (U.S.)
Concept Protein Disulfide-Isomerases
Concept 4-Aminobenzoic Acid
Concept Mitotic Index
Concept Serpins
Concept Cricetinae
Concept Cyclins
Concept X-Ray Diffraction
Concept Transcription Initiation Site
Concept Progesterone
Concept Drug Resistance, Multiple
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Leukemia L1210
Concept Binding, Competitive
Concept Blotting, Northern
Concept Dendritic Cells
Concept Epidemiologic Studies
Concept Genes
Concept Ovarian Neoplasms
Concept Algorithms
Concept Drug Delivery Systems
Concept Mice, Knockout
Concept Saccharomyces cerevisiae
Concept Antibodies
Concept Drug Evaluation
Concept Carbon-Sulfur Lyases
Concept Pyrazines
Concept Clinical Trials, Phase II as Topic
Concept Precipitin Tests
Concept Hydrogen Peroxide
Concept Ethylmaleimide
Concept Allyl Compounds
Concept Blotting, Western
Concept bcl-2-Associated X Protein
Concept Pancreatic Neoplasms
Concept 3T3 Cells
Concept Lipopolysaccharides
Concept Tumor Stem Cell Assay
Concept Cricetulus
Concept Hydrocortisone
Concept Genetic Predisposition to Disease
Concept Dual Specificity Phosphatase 1
Concept Lactoylglutathione Lyase
Concept Acetylcysteine
Concept Azoles
Concept Biopsy
Concept Dithiothreitol
Concept Immunoglobulins
Concept Prostate-Specific Antigen
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 11
Concept Dietary Supplements
Concept Up-Regulation
Concept Lymphocytes, Tumor-Infiltrating
Concept Caspase 3
Concept Obesity
Concept Serine Proteinase Inhibitors
Concept Genetic Techniques
Concept Chromatin
Concept Enzyme Induction
Concept Mice
Concept Clinical Trials as Topic
Concept Aging
Concept Tritium
Concept Cysteine
Concept Genetic Variation
Concept Immunoenzyme Techniques
Concept Histocytochemistry
Concept Kinetics
Concept Drug Evaluation, Preclinical
Concept Hep G2 Cells
Concept Isoenzymes
Concept Flavonoids
Concept Nitrogen
Concept Microscopy, Confocal
Concept Isoelectric Focusing
Concept Isoelectric Point
Concept Gene Expression Regulation, Developmental
Concept Chromatography, High Pressure Liquid
Concept Serum Albumin
Concept Estrogens
Concept Exons
Concept 5' Flanking Region
Concept Embryonic and Fetal Development
Concept Mice, Inbred C57BL
Concept Regulatory Sequences, Nucleic Acid
Concept Chromosomes, Human, Pair 9
Concept Hydroxyprostaglandin Dehydrogenases
Concept Gene Expression Regulation
Concept Psychomotor Agitation
Concept Enzyme Activation
Concept Sequence Deletion
Concept Estramustine
Concept Liver Neoplasms
Concept Mice, Transgenic
Concept T-Lymphocytes
Concept Cyclin-Dependent Kinase Inhibitor p57
Concept Zebrafish Proteins
Concept Esterification
Concept Nonmuscle Myosin Type IIA
Concept Drosophila
Concept Xenograft Model Antitumor Assays
Concept Severity of Illness Index
Concept Cell Proliferation
Concept Multiple Myeloma
Concept Survival Rate
Concept Hormones
Concept Humans
Concept Gonadal Steroid Hormones
Concept Down-Regulation
Concept Cattle
Concept Transgenes
Concept Prostate
Concept Colony-Forming Units Assay
Concept Mutation
Concept Multidrug Resistance-Associated Proteins
Concept alpha 1-Antitrypsin
Concept Membrane Glycoproteins
Concept Dacarbazine
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Hematopoietic Stem Cells
Concept Drug Screening Assays, Antitumor
Concept Reactive Oxygen Species
Concept Rabbits
Concept Ethacrynic Acid
Concept Ribonuclease, Pancreatic
Concept Bone Marrow
Concept Pain Measurement
Concept Electrophoresis, Polyacrylamide Gel
Concept Active Transport, Cell Nucleus
Concept Estradiol
Concept Colforsin
Concept Subrenal Capsule Assay
Concept Microscopy, Fluorescence
Concept Hydroquinones
Concept Sp3 Transcription Factor
Concept Nucleic Acid Hybridization
Concept Carcinoma, Non-Small-Cell Lung
Concept Caspases
Concept Sp4 Transcription Factor
Concept Leukotriene Antagonists
Concept CD11b Antigen
Concept Etoposide
Concept Gene Expression Regulation, Enzymologic
Concept Brain Injuries
Concept Mice, Inbred NOD
Concept Down Syndrome
Concept Dinitrophenols
Concept Antibodies, Monoclonal
Concept beta-Cyclodextrins
Concept Survival Analysis
Concept Crystallography, X-Ray
Concept Alkaline Phosphatase
Concept ATP-Binding Cassette Transporters
Concept Liver Cirrhosis, Alcoholic
Concept Sex Factors
Concept Lipopolysaccharide Receptors
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Peroxiredoxin VI
Concept Protease Inhibitors
Concept Atherosclerosis
Concept HL-60 Cells
Concept Micrococcal Nuclease
Concept Recombinant Fusion Proteins
Concept Receptors, Estradiol
Concept Cocaine
Concept Thiotepa
Concept Response Elements
Concept Estrone
Concept DNA, Neoplasm
Concept Phosphoric Diester Hydrolases
Concept Sequence Alignment
Concept Ribonucleases
Concept Niemann-Pick Diseases
Concept Polymorphism, Restriction Fragment Length
Concept Alzheimer Disease
Concept Carotenoids
Concept Protein Tyrosine Phosphatases
Concept Polychlorinated Biphenyls
Concept Amyloid Precursor Protein Secretases
Concept Carcinoma, Hepatocellular
Concept Genotype
Concept Leukemia, Experimental
Concept Polymorphism, Genetic
Concept Cycloheximide
Concept Mice, Nude
Concept Tunicamycin
Concept Mice, SCID
Concept Gene Library
Concept Mice, Inbred Strains
Concept Folic Acid Antagonists
Concept Trace Elements
Concept Gene Expression Regulation, Neoplastic
Concept Extracellular Signal-Regulated MAP Kinases
Concept Reproducibility of Results
Concept Fas Ligand Protein
Concept Gamma Rays
Concept Ovary
Concept Foam Cells
Concept JNK Mitogen-Activated Protein Kinases
Concept Antimetabolites, Antineoplastic
Concept Kidney Neoplasms
Concept Rats
Concept Immune System
Concept Proto-Oncogene Proteins p21(ras)
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept Hemoglobins
Concept Staining and Labeling
Concept Drug Resistance, Neoplasm
Concept Spleen
Concept Free Radicals
Concept Tremor
Concept Phytoestrogens
Concept Sp1 Transcription Factor
Concept Thymidine
Concept Alternative Splicing
Concept Chromosome Aberrations
Concept Proteomics
Concept Creatinine
Concept Enzyme Inhibitors
Concept Maleates
Concept Oligonucleotide Array Sequence Analysis
Concept B-Lymphocytes
Concept Transfection
Concept Hydrolysis
Concept Deoxyribonucleases
Concept Artemisinins
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept Rats, Sprague-Dawley
Concept Buthionine Sulfoximine
Concept Polymerase Chain Reaction
Concept Sulfides
Concept Paclitaxel
Concept Phosphodiesterase I
Concept Colon
Concept Phenols
Concept Hypercholesterolemia
Concept Mice, Inbred DBA
Concept Cell Shape
Concept In Situ Hybridization, Fluorescence
Concept Asthma
Concept Risk Factors
Concept MAP Kinase Kinase 4
Concept Promoter Regions, Genetic
Concept Epoxy Compounds
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Fluorescent Antibody Technique, Indirect
Concept Cyclic AMP
Concept Base Sequence
Concept Alleles
Concept Cloning, Molecular
Concept Deoxyribonuclease I
Concept Gene Knockdown Techniques
Concept Receptors, Estrogen
Concept Transcriptional Activation
Concept In Situ Nick-End Labeling
Concept Micronucleus Tests
Concept Carcinoma, Small Cell
Concept Immunohistochemistry
Concept Drug Combinations
Concept Colonic Neoplasms
Concept Larva
Concept Sexual Dysfunction, Physiological
Concept Immunoblotting
Concept Diethylstilbestrol
Concept Guanosine Diphosphate
Concept Chemokine CXCL12
Concept Estrogen Receptor alpha
Concept Glucose
Academic Article Editor's Note.
Academic Article Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells.
Academic Article Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.
Academic Article Redox pathways in cancer drug discovery.
Academic Article Selenocompounds in Cancer Therapy: An Overview.
Academic Article Pharmacology of ME-344, a novel cytotoxic isoflavone.
Academic Article A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities.
Academic Article Oxidative stress induces senescence in breast cancer stem cells.
Academic Article Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1.
Academic Article Racial disparities, cancer and response to oxidative stress.
Academic Article S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients.
Academic Article Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection.
Academic Article Altered redox regulation and S-glutathionylation of BiP contribute to bortezomib resistance in multiple myeloma.
Academic Article Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish.
Academic Article Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair.
Academic Article Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone.
Academic Article Oxidative Stress in Cancer.
Academic Article Development of Telintra as an Inhibitor of Glutathione S-Transferase P.
Academic Article Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Concept Molecular Targeted Therapy
Concept Transcriptome
Concept Proteasome Inhibitors
Concept para-Aminobenzoates
Concept Hydroxybenzoates
Concept Copper-transporting ATPases
Concept Radiation Exposure
Concept Bortezomib
Concept Ku Autoantigen
Academic Article Cisplatin chemotherapy and renal function.
Academic Article Reductive stress in cancer.
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